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Time temperature indicator (TTI) is an intelligent tool to monitor and record directly the time-temperature history of cold chain and indicate quality of corresponding agriculture produce. Because of the restriction of classic matching condition, TTI has not been widely used in a wide variety of agricultural produces. Even when the TTI satisfies the conditions, the reliability of application is significantly affected by the unstable primary quality of agricultural produces. The application of TTI is expanded through adjusting its parameters, and determining the requirements for matching with agricultural produces and the calibration procedure of TTI. The result deduced through the reaction kinetics equations and contour diagram indicated that the only matching condition was activation energy of TTI should equal to the parameter of agricultural produce, or there existed a proportional relationship between the contour lines of the two products. Besides, an adjusting process of TTI should be used with the new matching condition together. Considering a change of the state of TTI and agricultural produces, the calibration process was divided into two parts: first was the static model with the two produces’ state which were static, and the second was the dynamic model with both of the two produces were in constant change. It provided corresponding theory and methods by using the Arrhenius equations and contour diagram for the two calibration process respectively. These calibration methods can expand the application of TTI and improve the precision and reliability of monitoring the quality of agricultural produces. Finally, the validity and reliability of the calibration theory were illustrated with an example by using two types of enzymatic TTIs, two types of chemical TTIs and Muscat grape.